The Fisher Drug Discovery Resource Center (DDRC) at The Rockefeller University guides and supports researchers in drug discovery by improving the efficiency of their bioassays, identifying compounds for drug refinement and development, addressing the molecular targets for drugs, and in utilizing technologies for the measurement of drug/receptor interactions. The DDRC has a collection of 420,000 drug-like compounds, along with semi-automated liquid pipetting devices, bioassay instruments, and computational techniques for supporting drug discovery programs.
Core Technologies/Services
The DDRC provides scientific and technical support and access to instrumentation in the following areas:
- Assay Cascades used in drug discovery projects
- Miniaturized assay development
- High-throughput screening
- Identifying compounds for drug discovery or biomedical research
- Measuring the kinetics and thermodynamics of biomolecular interactions
Equipment
Automated Liquid Dispensing
- Perkin-Elmer Janus Automated Workstation
- Thermo MultiDrop Combi
- Biotek MultiFlo
- Biotek EL406 Microtiter Plate Washer with BioStack automated plate feeder
Microplate Readers and Analytical Instruments
- Molecular Devices ImageXpress Micro XL
- Biotek Synergy NEO.
- LICOR Odyssey M
- SeaHorse XF96 Extracellular Flux Analyzer
Surface Plasmon Resonance (SPR)
- Biacore 8K
Microscale Thermophores
- Nano Temper MST monolith 115
Circular Dichroism
- Applied Photophysics Chriascan V-100
- Circular Dichroism Spectrometer
Dynamic Light Scattering
- Wyatt Dynapro Plate Reader
Differential Scanning Fluorimetry (Thermal Melt Analysis)
- Bio-Rad CFX 96
Isothermal Tiration Calorimetry
- Malvern ITC200
High Throughput Mass Spectrometry
- Agilent RapidFire 360 System
See more here.