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Proteomics

Proteomics and Metabolomics Core Facility

Summary

Established in 2016, the Weill Cornell Medicine (WCM) Meyer Cancer Center Proteomics and Metabolomics Core Facility provides mass spectrometry based analysis of proteins, peptides, metabolites and other biochemical molecules.

The core facility is open to Weill Cornell Medicine users as well as external users from academic institutions and commercial enterprises.

Services

Protein Identification

Protein Quantitation

◦      Methods include: SILAC, TMT, Label-free, spiked standards, etc.

Post-Translational Modification Analysis (PTM)

◦      Phosphorylation, ubiquitination, acetylation, N/C-term processing, etc.

Targeted profiling of Polar Metabolites

◦      Targeted detection of metabolites in a predefined panel

Stable isotope tracing for polar metabolites

◦      Type 1: Targeted tracing of  selected metabolites

◦      Type 2: Full panel tracing (Exhaustive tracing of all detected metabolites. No need to know beforehand if a particular metabolite is labeled or not.) 

◦      e.g. C13 Glucose labeling

New Method Development

◦      User needs to provide standard compounds 

Resources

  • Orbitrap Fusion Lumos (with Easy-nLC 1200 UPLC) 
  • Orbitrap Q Exactive (with Easy-nLC 1200 UPLC Vanquish UPLC) 

Contact Information

Guoan Zhang, Ph.D.
Core Director, CLC Proteomics and Metabolomics Core Facility
Phone: (646) 962-6222
Email: guz2004@med.cornell.edu

More Information

For more information on service fees, instrumentation, and how to submit samples, please visit our iLab homepage.

Contact Information

Core Contact: Guoan Zhang, Ph.D.

Email: guz2004@med.cornell.edu

Phone: (646) 962-6222