The Applied Bioinformatics Core (ABC) is a central service group specializing in providing data management and analysis support to large genomic centers and research groups. ABC has expertise in analyzing biological data from diverse types of experiments, including high- throughput genomic assays, single cell experiments and spatial profiling platforms. The core has extensive experience building standardized workflows and customized, in-depth analyses, visualization and functional interpretation with emphasis on quality control and statistical rigor.
The Chemical Purification Core located in Room 1646, Belfer Research Building, offers state-of-the-art equipment, including analytical and preparative HPLC-MS, flash chromatography systems, and parallel evaporators, specifically for labs with 1-2 synthetic postdocs/technicians. Users have walk-up access to all instruments for an annual fee of $3,500, providing their own columns, solvents, and vials for preparative work.
The core supports the purification of organic compounds and organic synthesis at Weill Cornell Medical College, with walk-up access to:
The Citigroup Biomedical Imaging Center (CBIC) at Weill Cornell Medicine is a 15,000 square- foot research facility that houses the Biomedical Imaging Core. The CBIC provides state-of- the-art imaging instruments and expertise in their applications to the Weill Cornell Medicine community and outside investigators.
The Cryogenic Electron Microscopy Core (Cryo-EM) laboratory provides sample preparation equipment, a cryo transmission electron microscope, and service and training in all aspects of single particle electron microscopy. The Cryo-EM Core is continually implementing new equipment and methods to remain current.
The Epigenomics Core facility offers scientific support for researchers working on epigenetics and epigenomics. The core provides an array of epigenomics and bioinformatics research resources including scientific consultation, experimental implementation, data processing, bioinformatics analysis, and data storage. The goal of the Epigenomics
Core is to be at the developing edge of new methodologies, both experimentally and computationally.
The Fisher Drug Discovery Resource Center (DDRC) at The Rockefeller University guides and supports researchers in drug discovery by improving the efficiency of their bioassays, identifying compounds for drug refinement and development, addressing the molecular targets for drugs, and in utilizing technologies for the measurement of drug/receptor interactions. The DDRC has a collection of 420,000 drug-like compounds, along with semi-automated liquid pipetting devices, bioassay instruments, and computational techniques for supporting drug discovery programs.
The Genomics Resources Core Facility (GRCF) was established in 2000 and provides genomics technologies and related high-throughput technologies to the basic and translational research and clinical communities, including Weill Cornell Medicine, NewYork-Presbyterian Hospital, the Hospital for Special Surgery, and external collaborators. The full-range and high quality of Next Generation Sequencing (NGS) services include experimental design, sample manipulation, instrumentation, data analysis/interpretation, and validation.
The High-Performance Computing Core provides high performance scientific computing to researchers at Weill Cornell Medicine through cutting-edge computational resources, fast on-premises storage, software deployment, application hosting, consulting and much more. Our team of engineers and developers can assist researchers in all stages of your HPC projects. We will forecast system requirements, provisioning, deployment, and monitoring of software and hardware for your research projects.
The Weill Cornell Medicine Human Therapeutic Organoid Core (HTOC) facility serves as a central facility for human organoid technology to accelerate organoid-based scientific discovery. Organoids are mini-organs in a dish, made up of cells that self-organize and can more accurately recapitulate human biology. Human organoid technology has arisen as one of the best models to study human development and disease. The core facility will provide human pluripotent stem cell (hPSC) derived as well as tissue derived organoids as a fee-for-service.
The Institutional Biorepository Core (IBC) was launched in 2017 to provide Weill Cornell Medicine (WCM) investigators with a mechanism to attain high-quality human biospecimens for their research needs.
The overarching goal of the core is to facilitate basic, translational, and clinical research.
• Cross-departmental center supporting all phases of human biospecimen acquisition, analysis, and distribution
• Centralized services for collection, processing, storage, and distribution of solid and liquid biospecimens
The Metabolic Phenotyping Center (MPC) offers an extensive range of services for comprehensive metabolic phenotyping in the mouse. Our extensive variety of state-of-the-art metabolic research equipment coupled with technical expertise allows the MPC to comprehensively assess murine metabolism. We work with Weill Cornell Medicine investigators to custom design investigations of dietary or microbiome manipulation, experimental drug treatment, or genetic mutation to help them answer their experimental questions.
The Microbiome Core specializes in bacterial analysis and provides institutional sample-to-data processing services, and accepts a wide variety of sample types (mouse/rat feces, human feces, human/animal swabs, pelleted cells, or just extracted DNA). With a streamlined and highly efficient process, the Microbiome Core can deliver data to customers anywhere in the world in as little as three weeks.
The Microscopy and Image Analysis Core is comprised of three labs: Optical Microscopy, Automated Microscopy, and Electron Microscopy and Histology. The labs were established in 1998 and provide extensive training on the independent use of microscopes to Weill Cornell Medicine research faculty and staff, postdoctoral fellows, and graduate and medical students.
The Molecular Biophysics Core, situated at 1300 York in Rooms C507/C511, is designed to support both novice and advanced users in the purification and characterization of macromolecules, streamlining these processes efficiently. The facility is outfitted with a variety of instruments and offers extensive services to facilitate the functional and biophysical characterization of proteins, liposomes, proteo-liposomes, and other macromolecules.
The Neuroanatomy Electron Microscopy Core provides training and services in experiments on brain tissue. These primarily include histology, pre-embedding light, electron microscopic immunocytochemical methods, and in situ hybridization techniques. The core also assists with the planning of anatomical experiments as well as data collection, analysis, and interpretation.
The Weill Cornell Medicine Proteomics and Metabolomics Core Facility was established in 2016 and provides mass spectrometry-based analysis of proteins, peptides, metabolites, and other biochemical molecules to WCM users, as well as external users from outside academic institutions and commercial enterprises.