Overview of Services
The Chemical Purification Core located in Room 1646, Belfer Research Building, offers state-of-the-art equipment, including analytical and preparative HPLC-MS, flash chromatography systems, and parallel evaporators, specifically for labs with 1-2 synthetic postdocs/technicians. Users have walk-up access to all instruments for an annual fee of $3,500, providing their own columns, solvents, and vials for preparative work.
The core supports the purification of organic compounds and organic synthesis at Weill Cornell Medical College, with walk-up access to:
1. Prep HPLC-MS with ELSD, UV/Vis, MS detection (Waters Autopure)
2. Prep HPLC-MS with UV/Vis, MS detection (Waters Autopure)
These two instruments are used for rapid and fully automated purification of 1-100 mg of organic molecules from complex reaction mixtures, with online MS, UV/Vis, and ELSD detection. They can also be operated in analytical mode with < 1 mg of sample, for monitoring reaction progress and assessing compound purity.
3. Centrifugal Evaporator (Genevac EZ2.4 Elite HCl Compatible)
4. Centrifugal Evaporator (Genevac EZ2.4 Elite HCl Compatible)
These instruments are used for parallel evaporation of purified organic compounds, and are capable of removing organic solvents and mineral acids.
5. Medium pressure flash chromatography (Teledyne Isco RF+)
6. Medium pressure flash chromatography (Teledyne Isco RF+)
These instruments are used for rapid flash purification of UV/Vis active molecules via both normal phase and reverse phase chromatography. They are best suited to purification of 10 mg – 5 g of crude mixtures.
7. Kilo-scale flash chromatography (Teledyne Isco CombiFlash Torrent)
This is used for very large scale purification of organic mixtures (50-500g)
For access to the core please contact Mohammad Mansour and Jacob Geri. We will provide orientation to new users and will schedule a supplementary group training session on use of the prep HPLCMS instruments with a Waters technician.
To inquire about trainings for instruments, reach out to Jacob Geri.