Research Highlights and Publications

  • David Redmond (Assistant Professor of Computational Biology Research in Medicine), Fong Pan (Assistant Professor of Cell and Developmental Biology Research in Surgery), Jenny Xiang (Professor of Research in Microbiology and Immunology), Alain Charles Borczuk (Professor of Pathology and Laboratory Medicine), Fabrice Jaffre (Instructor of Cell and Developmental Biology in Surgery), Robert Schwartz (Assistant Professor of Medicine), Todd Evans (Professor of Cell and Developmental Biology in Surgery), David Lyden (Professor of Pediatrics), and Shuibing Chen (Associate Professor of Chemical Biology in Surgery): "A human pluripotent stem cell-based platform to study SARS-CoV-2 tropism and model virus infection in human cells and organoids," in Cell Stem Cell.

  • Steven Salvatore (Associate Professor of Clinical Pathology and Laboratory Medicine) and Alain Charles Borczuk (Professor of Pathology and Laboratory Medicine): "SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract," in Cell.

  • Dana J. Lukin (Associate Professor of Clinical Medicine), Anand Kumar (IBD Fellow), Kaveh Hajifathalian (Instructor in Medicine), Reem Z Sharaiha (Associate Professor of Medicine), Ellen J Scherl (Professor of Clinical Medicine), and Randy S Longman (Associate Professor of Medicine): "Baseline Disease Activity and Steroid Therapy Stratify Risk of COVID-19 in Patients with Inflammatory Bowel Disease," in Gastroenterology.

  • Lars Westblade (Associate Professor of Pathology and Laboratory Medicine), Thomas Walsh (Professor of Medicine), Peter Martin (Associate Professor of Medicine), Parag Goyal (Assistant Professor of Medicine), Monika Safford (Professor of Medicine),Melissa Cushing (Professor of Pathology and Laboratory Medicine), Markus Plate (Instructor in Medicine), Massimo Loda (Chairman of Pathology and Laboratory Medicine), Laura Pinheiro (Assistant Professor of Health Services Research in Medicine), Joseph Cooke (Associate Professor - Clinical), Jacob Rand (Professor of Pathology and Laboratory Medicine), Gagandeep Brar (Assistant Professor of Medicine), Catherine Small (Assistant Professor of Medicine (Interim)), and Michael Satlin (Assistant Professor of Medicine): "SARS-CoV-2 viral load predicts mortality in patients with and without cancer who are hospitalized with COVID-19," in Cancer Cell.

  • Yuling Han (Postdoctoral Associate in Surgery), Robert E. Schwartz (Assistant Professor of Medicine) and Shuibing Chen (Associate Professor of Chemical Biology in Surgery): Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids in Nature. https://pubmed.ncbi.nlm.nih.gov/33116299/

  • Kaveh Hajifathalian (Instructor in Medicine), Tibor Krisko (Assistant Professor of Medicine), Amit Mehta (Gastroenterology Fellow), Sonal Kumar (Assistant Professor of Medicine), Robert Schwartz (Assistant Professor of Medicine), Brett Fortune (Associate Professor of Medicine) , Reem Z. Sharaiha (Associate Professor of Medicine), and WCM-GI research group: Gastrointestinal and hepatic manifestations of 2019 Novel Coronavirus diseases in a large cohort of infected patients from New York: clinical implications in Gastroenterology.

  • Kaveh Hajifathalian (Instructor in Medicine), Sonal Kumar (Assistant Professor of Medicine), Carolyn Newberry (Assistant Professor of Medicine), Shawn Shah (Gastroenterology and Hepatology Fellow), Brett Fortune (Associate Professor of Medicine), Tibor Krisko (Assistant Professor of Medicine), Shiara Ortiz-Pujols (Resident), Xi Kathy Zhou (Associate Professor of Biostatistics in Population Health Sciences), Andrew J Dannenberg (Professor of Medicine), Rehka Kumar (Assistant Professor of Medicine), Reem Z Sharaiha (Associate Professor of Medicine): Obesity is associated with worse outcomes in COVID-19: Analysis of early data from New York City in Obesity.

  • Shuibing Chen (Kilts Family Associate Professor of Surgery), Todd Evans (Associate Dean for Research and Peter I. Pressman, M.D. Professor in Surgery), Robert Schwartz (Associate Professor of Medicine in the Division of Gastroenterology and Hepatology) and colleagues at other institutions used a laboratory system to grow different kinds of cells together to study the heart-damaging process in COVID-19.  In the study published April 15 in Circulation Research, the authors found that the heart damage seen in many severely ill COVID-19 patients results in part from infection-activated immune cells called macrophages, which infiltrate the heart and secrete cell-damaging mediators. The authors were also able to use the system to identify two existing United States Food and Drug Administration (FDA)-approved drugs that may be able to prevent or ameliorate this type of cardiac complication in COVID-19 patients.

  • Robert Schwartz (Associate Professor of Medicine), Olivier Elemento (Professor of Physiology and Biophysics), Alain Borczuk (Professor of Pathology and Laboratory Medicine), Christopher Mason (Professor of Physiology and Biophysics), and Steven Salvatore (Associate Professor of Clinical Pathology and Laboratory Medicine): "The spatial landscape of lung pathology during COVID-19 progression,” in Nature.