External Deadline: September 3, 2025 Internal Deadline: July 21, 2025
Instructions for electronic submission: To apply for the Endeavor Awards, please submit the materials requested below to this link no later than July 21, 2025, at 11:59 PM.
Program Description:
The Mark Foundation Endeavor Awards support collaborative research projects that bring together investigators with diverse areas of expertise to tackle challenges in the prevention, diagnosis, and treatment of cancer. These grants are awarded to teams of three or more investigators to generate and integrate data from diverse lines of research and transform those insights into advances for cancer patients that could not be achieved by individual efforts. A description of the teams granted Endeavor Awards in 2023 can be found here.
Team Composition:
- Teams must be composed of one PI and 2-8 co-PIs (see “Team Roles” section for definitions).
- Inter-institutional collaborations are permitted and encouraged.
- Teams are encouraged to consider diversity in terms of discipline, seniority, gender, race, ethnicity, and any other parameters that will enhance the team’s ability to approach challenging problems from fresh perspectives.
- The Mark Foundation for Cancer Research does not discriminate on the basis of race, color, religion, national origin, sex, gender identity, sexual orientation, age, disability, or any other legally protected characteristics.
Team Roles:
Principal Investigator (PI) – 1 per team
- Serves as the single point of contact with The Mark Foundation during the application process and the grant period.
- The LOA will be executed solely with the PI’s institution.
- Must meet all criteria of a co-PI listed below.
- Does not need to be the most senior member of the team.
Co-Principal Investigator (co-PI) – 2 to 8 per team
- Lab receives at least 10% of the total grant budget.
- Core member of the team’s leadership.
- Designated as key personnel in the LOA.
- Must have an independent faculty research appointment (tenure-track or equivalent).
Collaborator – optional
- Lab receives 0-10% of the budget.
- Can provide resources, perform experiments, analyses, etc.
- Serves as a project consultant or advisor rather than a team leader.
Number of Applications:
Up to two (2) submissions from WCM. One (1) application for any cancer type, and one (1) for a translational or clinical stage project that primarily focuses on one of the following four cancer types: upper GI, glioblastoma, triple-negative breast cancer, or pancreatic cancer.
Budget:
- Endeavor Awards are $3,000,000, disbursed over a 3-year term.
- The requested funding should be divided amongst team members in a manner proportional to the actual cost of the work carried out by each investigator for the project.
- The budget limit includes both direct and indirect costs, with indirect costs not to exceed 10% of the direct costs.
- The letter of agreement will include IP terms with a revenue-sharing component.
Eligibility
Institutional Eligibility:
- The “host institution” is the institution of the Principal Investigator on the application. There are no institutional restrictions for Co-Investigators - investigators from a given institution may be Co-Investigators on an unlimited number of applications.
- There is no requirement to include a US-based institution as part of the team.
- Teams may comprise investigators from a single institution or multiple institutions. The PI’s institution will be considered the host institution.
Investigator Eligibility:
- There are no restrictions on citizenship or geography.
- Applicants must have an independent faculty appointment (tenure-track or equivalent) at a non-profit academic/research institution.
- Investigators may be a co-PI or collaborator on more than one proposal, but may only serve as Principal Investigator on one proposal.
- Investigators who are currently a co-PI on an Endeavor team are permitted to apply as co-PI or collaborator on a new application.
Project Eligibility:
- Basic, translational, and clinical projects are eligible.
- The project must seek to address an overarching, urgent scientific question.
- Sub-projects should be designed to elucidate various aspects of the overarching question, theme, or focus.
- The output of the individual team members (data, samples, hypotheses, compounds, etc.) must be integrated and/or shared in a way that makes the impact of the project as a whole larger than the sum of its parts.
- Proposed projects must not be supported by other sources of funding. Finalists will be asked to discuss any potential overlap with other current or pending awards.
- We welcome projects addressing substantial unmet needs in any type of cancer. We particularly encourage teams with innovative ideas for therapeutic strategies for upper GI, glioblastoma, triple-negative breast cancer, and pancreatic cancer to consider applying in this round.
Application Requirements
Weill Cornell Medicine is limited to submitting 2 proposals. Due to this limitation an internal selection process will be coordinated. Chairpersons/Division Heads/Institute Directors may submit no more than two nominations from their department/division/institute.
Chairs/Division Heads/Institute Directors submitting more than one nomination must send a description on the relative strengths and weaknesses of the two nominees to researchdean@med.cornell.edu.
Submissions should contain the following information:
1. Letter of nomination by the Department Chair/Division Head/Institute Director (1-2 pages)
2. Project description (2-page limit). Including figures and tables but excluding literature references. Must include:
- Project Title
- Specific aims
- Introduction, background, and description of unmet need
- Research plan broken into aims, with each aim having:
- Clear objective
- Preliminary studies, if applicable
- High-level description of the experimental approach
- Milestones and timelines
- Future directions – if the research plan is successful, what is the 5-10-year vision for expansion of the project?
- Literature cited (does not count against page limit)
3. Team Description (1 page limit)
- List all co-Principal Investigators (co-PIs), and collaborators (name, institution, title, contact info)
- For the PI and co-PIs, provide 1-3 sentences describing their role in the project.
4. Principal Investigator’s Biosketch in NIH Format
5. Brief budget justification
Submit the items listed above here no later than July 21, 2025, at 11:59 PM in the order listed as one PDF document using the naming convention Candidate’s last name-first initial_ Endeavor2025.pdf (see example below).
Example: Smith-J_ Endeavor2025.pdf