​Laboratory of Comparative Pathology Services

The Laboratory of Comparative Pathology offers the following services: Anatomic Pathology, Clinical Pathology, Histotechnology and Immunohistochemistry.

​Anatomic Pathology 

Complete anatomic pathologic examinations, including gross and histopathologic analyses, are performed by board-certified American College of Veterinary Pathologists (ACVP)  anatomic pathologists. In addition, examination of tissue biopsies and slide evaluations are available.
Anatomic Pathology cells

Clinical Pathology

Scientists working on in-house clinical pathology services.

Clinical pathology services include: hematology (complete blood counts with white blood cell differentials, serum biochemical panels, hormone levels); parasitology; microbiology (bacterial and fungal identification, antimicrobial sensitivity); analysis of urine and other body fluids; serology for numerous bacterial, viral and parasitic infectious agents; and, environmental monitoring. All tests are performed by qualified laboratory professionals trained in veterinary laboratory techniques. The laboratory staff is committed to research in improved diagnostics, reference range development and state-of-the art assays. New tests are continuously being added as experimental needs change. The LCP also utilizes a network of reference laboratories to provide tests that are not performed in-house.   


Experienced histology technicians provide complete histology services including tissue processing, paraffin embedding, and sectioning. Routine stains such as hematoxylin & eosin, special histochemical stains, and immunohistochemistry are also performed. 

Subcutaneous hemangiosarcomas in a P53 homozygous knockout mouse. Hematoxylin and Eosin, 40x. Courtesy of Dr. Krista La Perle.


Immunohistochemistry (IHC) allows simultaneous evaluation of protein expression and tissue morphology on histological sections. The range of applications in pathology and biomedical research is wide and includes tumor subclassification, and assessment of cell proliferation, apoptosis, angiogenesis and signal transduction.
Mouse adrenal

Chromogranin A, mouse adrenal, pheochromocytoma

Mouse small intestine

E-cadherin, mouse small intestine, normal

Mouse brain

GFAP, mouse brain, normal

Mouse lymph node

Cleaved caspase-3, mouse lymph node, lymphoma


Cell type markers

  • Actin, muscle
  • Actin, smooth muscle
  • B220 (CD45R)
  • CD3 (all species, h)
  • CD4 (m, h)
  • CD8 (m, h)
  • CD11b
  • CD11c
  • CD19 (m, h)
  • CD31
  • CD34
  • CD45 (m, h)
  • Chromogranin A
  • C-kit 
  • Cytokeratin 5
  • Cytokeratin 7
  • Cytokeratin 8/18
  • Cytokeratin 14
  • Cytokeratin WSS (Pan-cytokeratin)
  • F4/80
  • Foxp3
  • GFAP
  • Granzyme B
  • lba1
  • Ly6G
  • Mac-2
  • Mitochondrial antigen (h)
  • Myeloperoxidase
  • Neuronal nuclei
  • NKp46
  • S100
  • Synaptophysin
  • TER-119
  • Vimentin
  • von Willebrand Factor



Proliferation markers and cell cycle

  • BrdU
  • Cyclin D1
  • Ki67

Apoptosis and anti-apoptosis markers

  • Cleaved caspase-3  
  • TUNEL (not an IHC method)

Angiogenesis markers

  • CD31 (m, h)
  • CD34
  • von Willebrand Factor

Tags and reporters

  • FLAG
  • GFP
  • Luciferase


  • Chlamydia
  • C-Myc
  • E-cadherin
  • Kim-1
  • Laminin
  • Lysozyme
  • NGAL
  • p53
  • PD-1 (m)
  • PD-L1 (m, h)
  • Phospho-Akt
  • Phospho-Erk
  • Phospho-histone H2A.X
  • VEGF

m: mouse specific, h: human specific

- Unless indicate, stains are optimized and validated for formalin or paraformaldehyde fixed paraffin embedded (FFPE) mouse tissues. For staining of samples prepared differently, or from other species, please consult the laboratory before submitting samples.


- For all immunofluorescence, please consult the laboratory before submitting samples.


- For advice on sample preparation and selection of appropriate markers, please consult an LCP technician or pathologist prior to submission.


- Evaluation of IHC slides by an LCP pathologist is available; additional charges apply for this service.