"Bridging the Gap Between Cellular and Mesoscopic Brain Imaging"

Part of the Progress in Neuroscience Seminar (PINS) series Serge Charpak, M.D., Ph.D. Inserm Research Director Abstract "I will describe a decade of research on how functional imaging based on blood flow dynamics actually reports neuronal activation. Our approach is based on two-photon microscopy imaging of cellular activity, functional ultrasound imaging of blood volume (fUS) and BOLD fMRI in the rodent brain." Publications Aydin AK, Haselden WD, Goulam Houssen Y, Pouzat C, Rungta RL, Demené C, Tanter M, Drew PJ, Charpak S, Boido D. (2020) Transfer functions linking neural calcium to single voxel functional ultrasound signal, Nat Commun. 11:2954. doi: 10.1038/s41467-020-16774-9.Boido D, Rungta RL, Osmanski BF, Roche M, Tsurugizawa T, Le BD, Ciobanu L, Charpak S (2019) Mesoscopic and microscopic imaging of sensory responses in the same animal. Nat Commun 10:1110. doi: 10.1038/s41467-019-09082-4Rungta RL, Chaigneau E, Osmanski BF, Charpak S (2018) Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia. Neuron 99:362-375. doi: 10.1016/j.neuron.2018.06.012Parpaleix A, Houssen YG, Charpak S (2013) Imaging local neuronal activity by monitoring PO(2) transients in capillaries. Nat Med 19:241-246. doi: 10.1038/nm.3059