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Visual Function
Summary
The Visual Function Core was established in 2017. This core provides an eye phenotype evaluation service to all investigators at Weill Cornell Medicine, Cornell University and Cornell-affiliated institutions. The facility also provides services to external investigators at both academic institutions and commercial enterprises.
Overview
Quantitative vision tests in animals
- Electroretinography (ERG), gives an assessment of scotopic (low light) and photopic (daylight) vision. ERG also provides insight into which cells may have a deficit in visual perception.
- Optomotor response (OMR), assessment provides a measure of visual acuity and contrast sensitivity.
Eye imaging in live animals
- Slit lamp gross morphology evaluation of the anterior or posterior of the eye.
- Optical Coherence Tomography (OCT) imaging yields a cross-sectional view of the retina and optic nerve.
- Angiography of both retinal blood flow (with fluorescein) and choroidal blood flow (with indocyanine green).
- Retinal cameras provide complementary imaging of the front and back of the eye.
Histological analysis of the eye
- Morphological analysis of the eye. Sectioning by various techniques, retinal & corneal flat mounts can be stained by immunofluorescence and other staining such as H&E.
Reporting service
- Primarily offered as a screening service for mutant mouse strains, this service provides a basic report on visual function and eye morphology. Detailed reports are also available.
Links to More Information
To Submit Samples, View Fee Schedule & for More information visit us at the WCM iLab portal.
Services
Quantitative vision tests in animals
- Electroretinography (ERG), gives an assessment of scotopic (low light) and photopic (daylight) vision. ERG also provides insight into which cells may have a deficit in visual perception.
- Optomotor response (OMR), assessment provides a measure of visual acuity and contrast sensitivity.
Eye imaging in live animals
- Slit lamp gross morphology evaluation of the anterior or posterior of the eye.
- Optical Coherence Tomography (OCT) imaging yields a cross-sectional view of the retina and optic nerve.
- Angiography of both retinal blood flow (with fluorescein) and choroidal blood flow (with indocyanine green).
- Retinal cameras provide complementary imaging of the front and back of the eye.
Histological analysis of the eye
- Morphological analysis of the eye. Sectioning by various techniques, retinal & corneal flat mounts can be stained by immunofluorescence and other staining such as H&E.
Reporting service
- Primarily offered as a screening service for mutant mouse strains, this service provides a basic report on visual function and eye morphology. Detailed reports are also available.
Resources
- Diagnosys ERG: Espion E3 Console with ColorDome Ganzfeld and Pattern Stimulator PSG
- Heidelberg Engineering, Spectralis Tracking OCT System, HRA+OCT Advanced with Quantitative Autofluorescence Module
- Phoenix Research Labs Micron III retinal microscope
- Custom engineered OMR analysis system based on the OMR Arena
- Nikon FS-3 Zoom Photo Slit Lamp
Contact Information
Ryan Schreiner, Ph.D.
Core Director, CLC Visual Function Core Facility
Phone: (646) 373-5705
Email: rps2001@med.cornell.edu
CLC Visual Function Core Facility
1300 York Ave., E304
New York, NY 10065
Phone: (646) 373-5705
Shipping Address
413 East 69th Street, E304
New York, NY 10021
Phone: (646) 373-5705
Contact Information
Core Contact: Ryan Schreiner, Ph.D.
Email: rps2001@med.cornell.edu
Phone: (646) 373-5705