Visual Function

Summary

The Visual Function Core was established in 2017.  This core provides an eye phenotype evaluation service to all investigators at Weill Cornell Medicine, Cornell University and Cornell-affiliated institutions. The facility also provides services to external investigators at both academic institutions and commercial enterprises.

 

Overview

Quantitative vision tests in animals

  • Electroretinography (ERG), gives an assessment of scotopic (low light) and photopic (daylight) vision. ERG also provides insight into which cells may have a deficit in visual perception.
  • Optomotor response (OMR), assessment provides a measure of visual acuity and contrast sensitivity.  

Eye imaging in live animals

  • Slit lamp gross morphology evaluation of the anterior or posterior of the eye.
  • Optical Coherence Tomography (OCT) imaging yields a cross-sectional view of the retina and optic nerve. 
  • Angiography of both retinal blood flow (with fluorescein) and choroidal blood flow (with indocyanine green). 
  • Retinal cameras provide complementary imaging of the front and back of the eye.

Histological analysis of the eye

  • Morphological analysis of the eye.  Sectioning by various techniques, retinal & corneal flat mounts can be stained by immunofluorescence and other staining such as H&E.

Reporting service

  • Primarily offered as a screening service for mutant mouse strains, this service provides a basic report on visual function and eye morphology.  Detailed reports are also available.

Links to More Information

To Submit Samples, View Fee Schedule & for More information visit us at the WCM iLab portal.

Services

Quantitative vision tests in animals

  • Electroretinography (ERG), gives an assessment of scotopic (low light) and photopic (daylight) vision. ERG also provides insight into which cells may have a deficit in visual perception.
  • Optomotor response (OMR), assessment provides a measure of visual acuity and contrast sensitivity.  

Eye imaging in live animals

  • Slit lamp gross morphology evaluation of the anterior or posterior of the eye.
  • Optical Coherence Tomography (OCT) imaging yields a cross-sectional view of the retina and optic nerve. 
  • Angiography of both retinal blood flow (with fluorescein) and choroidal blood flow (with indocyanine green). 
  • Retinal cameras provide complementary imaging of the front and back of the eye.

Histological analysis of the eye

  • Morphological analysis of the eye.  Sectioning by various techniques, retinal & corneal flat mounts can be stained by immunofluorescence and other staining such as H&E.

Reporting service

  • Primarily offered as a screening service for mutant mouse strains, this service provides a basic report on visual function and eye morphology.  Detailed reports are also available.

Resources

  • Diagnosys ERG: Espion E3 Console with ColorDome Ganzfeld and Pattern Stimulator PSG
  • Heidelberg Engineering, Spectralis Tracking OCT System, HRA+OCT Advanced with Quantitative Autofluorescence Module
  • Phoenix Research Labs Micron III retinal microscope
  • Custom engineered OMR analysis system based on the OMR Arena
  • Nikon FS-3 Zoom Photo Slit Lamp

Contact Information

Ryan Schreiner, Ph.D.
Core Director, CLC Visual Function Core Facility
Phone: (646) 373-5705
Email: rps2001@med.cornell.edu

CLC Visual Function Core Facility
1300 York Ave., E304
New York, NY 10065
Phone: (646) 373-5705

Shipping Address
413 East 69th Street, E304
New York, NY 10021
Phone: (646) 373-5705

Contact Information

Core Contact: Ryan Schreiner, Ph.D.

Email: rps2001@med.cornell.edu

Phone: (646) 373-5705