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Research

Visual Function

Summary

The Visual Function Core was established in 2017.  This core provides an eye phenotype evaluation service to all investigators at Weill Cornell Medicine, Cornell University and Cornell-affiliated institutions. The facility also provides services to external investigators at both academic institutions and commercial enterprises.

 

Overview

Quantitative vision tests in animals

  • Electroretinography (ERG), gives an assessment of scotopic (low light) and photopic (daylight) vision. ERG also provides insight into which cells may have a deficit in visual perception.
  • Optomotor response (OMR), assessment provides a measure of visual acuity and contrast sensitivity.  

Eye imaging in live animals

  • Slit lamp gross morphology evaluation of the anterior or posterior of the eye.
  • Optical Coherence Tomography (OCT) imaging yields a cross-sectional view of the retina and optic nerve. 
  • Angiography of both retinal blood flow (with fluorescein) and choroidal blood flow (with indocyanine green). 
  • Retinal cameras provide complementary imaging of the front and back of the eye.

Histological analysis of the eye

  • Morphological analysis of the eye.  Sectioning by various techniques, retinal & corneal flat mounts can be stained by immunofluorescence and other staining such as H&E.

Reporting service

  • Primarily offered as a screening service for mutant mouse strains, this service provides a basic report on visual function and eye morphology.  Detailed reports are also available.

Links to More Information

To Submit Samples, View Fee Schedule & for More information visit us at the WCM iLab portal.

Services

Quantitative vision tests in animals

  • Electroretinography (ERG), gives an assessment of scotopic (low light) and photopic (daylight) vision. ERG also provides insight into which cells may have a deficit in visual perception.
  • Optomotor response (OMR), assessment provides a measure of visual acuity and contrast sensitivity.  

Eye imaging in live animals

  • Slit lamp gross morphology evaluation of the anterior or posterior of the eye.
  • Optical Coherence Tomography (OCT) imaging yields a cross-sectional view of the retina and optic nerve. 
  • Angiography of both retinal blood flow (with fluorescein) and choroidal blood flow (with indocyanine green). 
  • Retinal cameras provide complementary imaging of the front and back of the eye.

Histological analysis of the eye

  • Morphological analysis of the eye.  Sectioning by various techniques, retinal & corneal flat mounts can be stained by immunofluorescence and other staining such as H&E.

Reporting service

  • Primarily offered as a screening service for mutant mouse strains, this service provides a basic report on visual function and eye morphology.  Detailed reports are also available.

Resources

  • Diagnosys ERG: Espion E3 Console with ColorDome Ganzfeld and Pattern Stimulator PSG
  • Heidelberg Engineering, Spectralis Tracking OCT System, HRA+OCT Advanced with Quantitative Autofluorescence Module
  • Phoenix Research Labs Micron III retinal microscope
  • Custom engineered OMR analysis system based on the OMR Arena
  • Nikon FS-3 Zoom Photo Slit Lamp

Contact Information

Ryan Schreiner, Ph.D.
Core Director, CLC Visual Function Core Facility
Phone: (646) 373-5705
Email: rps2001@med.cornell.edu

CLC Visual Function Core Facility
1300 York Ave., E304
New York, NY 10065
Phone: (646) 373-5705

Shipping Address
413 East 69th Street, E304
New York, NY 10021
Phone: (646) 373-5705

Contact Information

Core Contact: Ryan Schreiner, Ph.D.

Email: rps2001@med.cornell.edu

Phone: (646) 373-5705

Office of the Research Dean Weill Cornell Medicine 1300 York Ave. New York, NY 10065 ResearchDean@med.cornell.edu